Voratex Drug Interactions

Patients should inform their doctor or pharmacist if they are taking, have recently taken or might take any other medicines, including those that are obtained without a prescription.
Some medicines, when taken at the same time as Voratex, may affect the way Voratex works or Voratex may affect the way they work.
Treatment with Voratex at the same time should be avoided if possible: Ritonavir in doses of 100 mg twice daily; Glasdegib (if both drugs need to be used, heart rhythm will be monitored frequently).
Treatment with Voratex at the same time should be avoided if possible, and a dose adjustment of voriconazole may be required: Rifabutin (if already being treated with rifabutin, blood counts and side effects to rifabutin will need to be monitored); Phenytoin (if already being treated with phenytoin, blood concentration of phenytoin will need to be monitored during treatment with Voratex and dose may be adjusted).
Dose adjustment or monitoring may be required to check that the medicines and/or Voratex are still having the desired effect: Warfarin and other anticoagulants (e.g., phenprocoumon, acenocoumarol); Ciclosporin; Tacrolimus; Sulfonylureas (e.g., tolbutamide, glipizide, and glyburide); Statins (e.g., atorvastatin, simvastatin); Benzodiazepines (e.g., midazolam, triazolam); Omeprazole; Oral contraceptives (if Voratex is taken whilst using oral contraceptives, side effects such as nausea and menstrual disorders may be experienced); Vinca alkaloids (e.g., vincristine and vinblastine); Tyrosine kinase inhibitors (e.g., axitinib, bosutinib, cabozantinib, ceritinib, cobimetinib, dabrafenib, dasatinib, nilotinib, sunitinib, ibrutinib, ribociclib); Tretinoin; Indinavir and other HIV protease inhibitors; Non-nucleoside reverse transcriptase inhibitors (e.g., efavirenz, delavirdine, nevirapine) (some doses of efavirenz cannot be taken at the same time as Voratex); Methadone; Alfentanil and fentanyl and other short-acting opiates such as sufentanil; Oxycodone and other long-acting opiates such as hydrocodone; Non-steroidal anti-inflammatory drugs (e.g., ibuprofen, diclofenac); Fluconazole; Everolimus; Letermovir; Ivacaftor.