Fe deficiency where there is a clinical need for rapid Fe supply. Fe deficiency in patients who cannot tolerate oral Fe therapy or who are non-compliant. Fe deficiency where oral Fe prep are ineffective (eg, active inflammatory bowel disease).
Adult 5-10 mL (100-200 mg Fe) 1-3 times per wk. Childn Max: 0.15 mL (3 mg Fe)/kg, not more than 3 times per wk. Administer by drip infusion, slow inj, or directly into the venous line of the dialysis machine. IV inj Max tolerated daily dose (not more than 3 times per wk): 10 mL (200 mg Fe) over at least 10 min. IV infusion Max tolerated daily dose (not more than once per wk): Adult weighing >70 kg 500 mg Fe over at least 3½ hr, ≤70 kg 7 mg Fe/kg over at least 3½ hr.
View Venofer overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity. IV Fe-containing products must not be used in patients w/ serious hypersensitivity to other parenteral Fe products. Anaemia not caused by Fe deficiency. Fe overload or disturbances in Fe utilisation. 1st trimester of pregnancy.
Risk of allergic or anaphylactoid reactions. Carefully monitor for signs & symptoms of hypersensitivity reactions during & following each administration. Observe for adverse effects for at least 30 min following each inj. Immediately stop administration in case of hypersensitivity reactions. Administer w/ caution in patients w/ history of asthma, eczema, other atopic allergies, or allergic reactions to other parenteral Fe prep. Use w/ caution in case of acute or chronic infection. Stop administration in patients w/ bacteraemia. Avoid paravenous leakage, & immediately stop administration if this occurs. Do not drive a car or use machines if symptoms eg, dizziness, confusion or light-headedness occur following administration. Administer in patients w/ liver dysfunction only after careful risk/benefit assessment. Avoid administration in patients w/ hepatic dysfunction where Fe overload is a precipitating factor. Use during the 2nd & 3rd trimesters of pregnancy only if potential benefit justifies potential risk to foetus. Assess benefit & risk of treatment during lactation. Moderate amount of data in childn.
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