Varivax Drug Interactions

Salicylates: No cases of Reye syndrome have been observed following vaccination with VARIVAX. Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with VARIVAX, as Reye syndrome has been reported following the use of salicylates during wild-type varicella infection [see Salicylate Therapy under Precautions].
Immune Globulins and Transfusions: Administration of immune globulins and other blood products concurrently with VARIVAX may interfere with the expected immune response [see Immune Globulins and Transfusions under Precautions]. The ACIP has specific recommendations for intervals between administration of antibody containing products and live virus vaccines.
Tuberculin Skin Testing: Tuberculin skin testing, with tuberculin purified protein derivative (PPD), may be performed before VARIVAX is administered or on the same day, or at least 4 weeks following vaccination with VARIVAX, as other live virus vaccines may cause a temporary depression of tuberculin skin test sensitivity leading to false negative results.
Use with Other Vaccines: VARIVAX can be administered concurrently with other live viral vaccines. If not given concurrently, at least 1 month should elapse between a dose of a live attenuated measles virus-containing vaccine and a dose of VARIVAX. In children through the age of 12 years at least 3 months should elapse between administration of 2 doses of a live attenuated varicella virus-containing vaccine. For adolescents and adults, 2 doses of VARIVAX may be separated by 4 to 8 weeks [see Recommended Dose and Schedule under Dosage & Administration].
VARIVAX may be administered concomitantly with M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live), Haemophilus influenzae type b conjugate (meningococcal protein conjugate) and hepatitis B (recombinant). Additionally, VARIVAX may be administered concomitantly with inactivated diphtheria-tetanus and acellular pertussis vaccines [see Pharmacology: Pharmacodynamics: Clinical Studies: Studies with Other Vaccines under Actions].