Solifenacin is contraindicated in: Patients with urinary retention, severe gastrointestinal condition (including toxic megacolon), myasthenia gravis or narrow-angle glaucoma and in patients at risk for these conditions; Patients hypersensitive to the active substance or to any of the excipients; Patients undergoing haemodialysis; Patients with severe hepatic impairment; Patients with severe renal impairment or moderate hepatic impairment and who are on treatment with a potent CYP3A4 inhibitor, e.g. ketoconazole.
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