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Patients for whom hemostatic management is difficult: intracranial hemorrhage, hemoptysis, retroperitoneal hemorrhage and the like.
Patients having undergone intracranial or spinal surgery or with such injury (in the last 2 months).
Patients with aneurysm.
Patients with serious disturbances of consciousness.
Contraindications as a general rule: This product is contraindicated in the following patients, as a general rule. If essential, however, it can be administered with caution.
1) Patients with atrial fibrillation (particularly with mitral stenosis), patients with infective endocarditis, patients with old myocardial infarction, and patients with a prosthetic valve.
2) Patients with neurological signs and symptoms of stroke which became complete instantaneously.
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