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Effect of Other Drugs on TREANDA: CYP1A2 Inhibitors: The coadministration of TREANDA with CYP1A2 inhibitors may increase bendamustine plasma concentrations and may result in increased incidence of adverse reactions with TREANDA (see Pharmacology: Pharmacokinetics under Actions). Consider alternative therapies that are not CYP1A2 inhibitors during treatment with TREANDA.
CYP1A2 Inducers: The coadministration of TREANDA with CYP1A2 inducers may decrease bendamustine plasma concentrations and may result in decreased efficacy of TREANDA (see Pharmacology: Pharmacokinetics under Actions). Consider alternative therapies that are not CYP1A2 inducers during treatment with TREANDA.
