Trajenta Duo is indicated in adults with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control: in patients inadequately controlled on their maximally tolerated dose of metformin alone; in combination with other medicinal products for the treatment of diabetes, including insulin, in patients inadequately controlled with metformin and these medicinal products; in patients already being treated with the combination of linagliptin and metformin as separate tablets (see Precautions, Interactions and Pharmacology: Pharmacodynamics under Actions for available data on different combinations).