Tislelizumab - Intravenous

Tislelizumab is used on its own or together with other medicines to treat cancer of the lung, oesophagus and stomach.

This medicine may be used to treat other conditions as decided by your doctor.

Tislelizumab injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of treatment depending on the type and severity of your condition and your response to the medication.

Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Tislelizumab.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.

Inform your doctor if you have the following conditions:

• brain cancer
• myasthenia gravis (muscle weakness disorder)
• autoimmune disease (condition wherein your immune system mistakenly attacks and destroys healthy body tissues)
• have had bone marrow transplant that used donor stem cells (allogeneic)
• hepatitis B (contagious liver infection caused by a virus that is spread through contact with infected blood or other body fluids)
• hepatitis C (contagious liver infection caused by a virus that is spread through exposure to infected blood [blood-to-blood contact])

Let your doctor know if you are pregnant. It is important that you do not get pregnant while being treated with this medicine. You must use effective birth control methods during Tislelizumab therapy and for at least 4 months after stopping the treatment. You may wish to discuss birth control methods with your doctor or pharmacist.

If you are breastfeeding, inform your doctor. You should not breastfeed during treatment and for at least 4 months after the last dose.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

• Screening and assessment of tumour status may be needed to check the appropriateness of Tislelizumab therapy.
• Pregnancy tests must be done before treatment to know if this medicine is suited for you to use.
• Routine tests (e.g. liver and kidney function, blood sugar level) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
• Regular monitoring of signs and symptoms of infusion reactions may also be needed.

Tislelizumab may cause any of the following side effects: nausea, itchy skin, muscle pain, and joint pain.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

• rashes, breathlessness, swelling of the face, eyes or mouth
• yellowing of the skin or eyes, abdominal pain, dark coloured urine, tiredness, swelling in the legs and ankles
• rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
• unusual bleeding or bruising
• frequent sore throat, mouth sores, fever, chills or sweating

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Inform your doctor and pharmacist if you are taking anti-inflammatory medicines.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.

Avoid alcohol.

Store in the refrigerator, between 2-8°C. Do not allow Tislelizumab to freeze. If frozen, this medicine will become ineffective and should not be used.

Protect from light.

Medicines must not be used past the expiry date.

As Tislelizumab is a cancer medicine, always return any unused or expired medicine to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.