Sign Out
Administration of TEMODAL with ranitidine or with food did not result in clinically significant alterations in the extent of absorption of TEMODAL. Co-administration of dexamethasone, prochlorperazine, phenytoin, carbamazepine, ondansetron, H2 receptor antagonists, or phenobarbital did not alter the clearance of TEMODAL. Co-administration with valproic acid was associated with a small but statistically significant decrease in clearance of temozolomide.
Use of TEMODAL in combination with other myelosuppressive agents may increase the likelihood of myelosuppression.
