TAKEPRON is contraindicated in patients with known severe hypersensitivity to any component of the formulation. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria (see Adverse Reactions).
For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with TAKEPRON, refer to the Contraindications section of their prescribing information.