Clindamycin has been associated with severe colitis which may end fatally. Cases of diarrhoea, bloody diarrhoea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with topical formulations of Clindamycin. Other local effects include contact dermatitis, irritation (e.g. erythema, peeling and burning), oily skin, skin dryness and gram-negative folliculitis. Clindamycin can also cause systemic effect such as abdominal pain, gastrointestinal disturbances.