Seroxat/Seroxat CR Overdosage

Symptoms and Signs: Seroxat: A wide margin of safety is evident from available overdose information on paroxetine.
Experience of paroxetine overdose has indicated that, in addition to those symptoms mentioned under Adverse Reactions, fever and involuntary muscle contractions have been reported. Patients have generally recovered without serious sequelae even when doses of up to 2000 mg have been taken alone. Events such as coma or ECG changes have occasionally been reported and, very rarely a fatal outcome, but generally when paroxetine was taken in conjunction with other psychotropic drugs, with or without alcohol.
Seroxat CR: The most commonly reported adverse events subsequent to paroxetine-only overdose include: somnolence, nausea, tremor, dizziness, vomiting, diarrhea, agitation, aggression, anxiety, confused state, headache, fatigue, insomnia, tachycardia, hyperhydrosis, mydriasis, convulsion, paraesthesia, serotonin syndrome, fever, blood pressure changes, involuntary muscle contraction and loss of consciousness. It should be noted that in some cases, patients may have consumed alcohol in addition to taking an overdose of paroxetine. Some of these symptoms may also be seen with clinical use.
Events such as coma or ECG changes have occasionally been reported.
Treatment: No specific antidote is known.
The treatment should consist of those general measures employed in the management of overdose with any antidepressant.
Seroxat: Administration of 20-30 g activated charcoal may be considered if possible within a few hours after overdose intake to decrease absorption of paroxetine. Supportive care with frequent monitoring of vital signs and careful observation is indicated. Patient management should be as clinically indicated.
Seroxat CR: Establish and maintain an airway; ensure adequate oxygenation and ventilation.
Induction of emesis is not recommended. Due to the large volume of distribution of SEROXAT CR, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit.
Supportive care with frequent monitoring of vital signs and careful observation is indicated. An ECG should be taken and monitoring of cardiac function instituted if there is any evidence of abnormality. Patient management should be as clinically indicated.
In managing overdosage, consider the possibility of multiple drug involvement.
A specific caution involves patients taking or recently having taken SEROXAT CR who might ingest, by accident or intent, excessive quantities of a tricyclic antidepressant. In such a case, accumulation of the parent tricyclic and its active metabolite may increase the possibility of clinically significant sequelae and extend the time needed for close medical observation.