Serimol

Serimol is a white, oblong-shaped tablet with characteristic markings.
Each tablet contains paracetamol 650 mg.

Paracetamol has analgesic and antipyretic properties.
The mechanism of its analgesic action is possibly by inhibition of prostaglandin synthesis. Paracetamol probably reduces fever by acting on hypothalamic heat-regulating center to increase sweating and heat loss.

Paracetamol is used for the symptomatic relief of fever, minor aches and pains.

Adults: 1 to 1 ½ tablets three or four times a day up to a maximum of 6 tablets daily.

Symptoms: Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, loss of appetite and abdominal pain. Liver damage (pain, tenderness, and/or swelling in the upper abdominal area) may become more apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, coma, and death. Acute renal failure with acute tubular necrosis may develop even in the absence of severe liver damage. Cardiac arrhythmias have been reported.
Treatment: Prompt treatment is essential in the management of paracetamol overdosage. Any patient who has ingested 7.5 g or more of paracetamol in the preceding 4 hours should undergo gastric lavage. The plasma or serum paracetamol concentration should be determined as soon as possible, but no sooner than 4 hours after ingestion. Acetylcysteine should be administered as soon as possible after ingestion of an overdose has been reported. Instituting haemoperfusion to remove paracetamol from the circulation may be beneficial if acetylcysteine administration cannot be instituted within 24 hours following ingestion. Supportive treatment including maintaining fluid and electrolyte balance, correcting hypoglycaemia should also be instituted.

Apart from hypersensitivity to paracetamol, which is rare, there are no known contraindications associated with its use.

This preparation contains PARACETAMOL.
Patients must be advised not to take other PARACETAMOL-containing medicines at the same time.
Patients must be advised not to exceed recommended dose.

Paracetamol should be given with care to patients with impaired kidney or liver function. Paracetamol should also be given with care to patients taking other drugs that affect the liver.
Use in Pregnancy & Lactation: See USE IN PREGNANCY & LACTATION section for further information.

Pregnancy: Problems in humans have not been documented.
Breast-feeding: Problems in humans have not been documented.

The side effects of paracetamol are usually mild, although haematological reactions have been reported. Skin rashes and other allergic reactions occur occasionally.

Alcohol, hepatic enzyme inducers, hepatotoxic medications: Risk of hepatotoxicity increased.

Store below 25°C.
Keep container tightly closed.
Protect from light.
Shelf Life: 36 months.

Analgesics (Non-Opioid) & Antipyretics

N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

P₂