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Concomitant Medication: Advise patients to inform their physician if they are taking or plan to take any prescription or over-the-counter drugs since there is a potential for interactions.
Strong and Moderate CYP3A inhibitors and P-gp inhibitors: Advise patients to inform their physician if they use strong (e.g., ketoconazole, itraconazole, clarithromycin, telithromycin, nelfinavir, saquinavir, indinavir, ritonavir) or moderate CYP3A inhibitors (e.g., aprepitant, erythromycin, diltiazem, verapamil, fluconazole) or P-gp inhibitors (e.g., cyclosporine) [see Co-Administration with CYP3A Inhibitors, CYP3A Inducers and P-gp Inhibitors under Dosage & Administration; Concomitant use of strong CYP3A inhibitors under Contraindications; Drug Interactions under Precautions; Effects of Drugs on Tolvaptan under Interactions].
Nursing: Advise patients not to breastfeed an infant if they are taking SAMSCA [see Nursing Mothers under Use in Pregnancy & Lactation].
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