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Caution should be exercised if any of the following medicines are being taken: Certain antidepressants (selective serotonin reuptake inhibitors, selective serotonin-norepinephrine reuptake inhibitors, tricyclic or tetracyclic antidepressants); Ciprofloxacin; Dextromethorphan; Sympathomimetics such as those present in eye drops, nasal and oral decongestants and cold medicine containing ephedrine or pseudoephedrine.
The use of Rasagiline together with the antidepressants containing fluoxetine or fluvoxamine should be avoided.
Patients who are starting treatment with Rasagiline should wait at least 5 weeks after stopping fluoxetine treatment.
Patients who are starting treatment with fluoxetine or fluvoxamine should wait at least 14 days after stopping Rasagiline treatment.
Caution should be exercised in patients who are smoking or who intend to stop smoking. Smoking could decrease the amount of rasagiline in the blood.
