Proton Drug Interactions

Taking Proton with other medicines: Advise the patient to inform the doctor or pharmacist if the patient is taking, has recently taken, or might take any other medicines. This includes medicines bought without a prescription. This is because Proton can affect the way some medicines work and some medicines can have an effect on Proton.
Proton should not be taken if the patient is taking a medicine containing nelfinavir (used to treat HIV infection).
Advise the patient to inform the doctor or pharmacist if the patient is taking any of the following medicines: Ketoconazole, itraconazole, posaconazole or voriconazole (used to treat infections caused by a fungus); Digoxin (used to treat heart problems); Diazepam (used to treat anxiety, relax muscles or in epilepsy); Phenytoin (used in epilepsy). If the patient is taking phenytoin, the patient should be monitored when starting or stopping taking Proton; Anticoagulant medication, such as warfarin or other vitamin K blockers; Rifampicin (used to treat tuberculosis); Atazanavir (used to treat HIV infection); Tacrolimus (in case of organ transplantation); St. John's wort (Hypericum perforatum) (used to treat mild depression); Cilostazol (used to treat intermittent claudication); Saquinavir (used to treat HIV infection); Clopidogrel (used to prevent blood clots (thrombi)); Erlotinib (used to treat cancer); Methotrexate (a chemotherapy medicine used in high doses to treat cancer) - if the patient is taking a high dose of methotrexate, the Proton treatment may temporarily be stopped.
Omeprazole may increase the methotrexate level temporary, withdrawal of omeprazole may need to consider.
Literature suggests that concomitant use of proton pump inhibitors with methotrexate (primarily at high dose) may elevate and prolong serum levels of methotrexate and/or its metabolite, possible leading to methotrexate toxicities. A temporary withdrawal of the proton pump inhibitors may be considered in some patients receiving treatments with high dose methotrexate.
Case reports, published population pharmacokinetic studies, and retrospective analyses suggest that concomitant administration of proton pump inhibitors and methotrexate (primarily at high dose) may elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexate. However, no formal drug interaction studies of methotrexate with proton pump inhibitors have been conducted.
Avoid concomitant use of clopidogrel and omeprazole. Coadministration of clopidogrel with 80 mg omeprazole, a proton pump inhibitors that is an inhibitor of CYP2C19, reduces the pharmacological activity of clopidogrel if given concomitantly or if given 12 hours apart.
If the antibiotics amoxicillin and clarithromycin as well as Proton to treat ulcers caused by Helicobacter pylori infection have been prescribed, it is very important to advise the patient to inform the doctor about any other medicines being taken.
Proton with food and drink: Proton can be taken with food or on an empty stomach.