Drug Interactions Overview: Bile acid sequestering agents may interfere with the action of ursodiol by reducing absorption. Aluminum-based antacids adsorb bile acids
in vitro and may act in the same manner as sequestering agents, thereby interfering with the action of ursodiol. Ursodiol has been shown to be an inducer of CYP3A however the clinical relevance is not known. Metabolic interactions with compounds metabolized by cytochrome P4503A are to be expected.
Drug-Behavioural Interactions: Interactions with behaviour have not been established.
Drug-Drug Interactions: See Table 10.
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Drug-Food Interactions: Interactions with food have not been established.
Drug-Herb Interactions: Interactions with herbal products have not been established.
Drug-Laboratory Test Interactions: Interactions with laboratory tests have not been established.