pms-Bortezomib Special Precautions

Patients must be advised to inform the doctor if they have any of the following: low numbers of red or white blood cells; bleeding problems and/or low number of platelets in the blood; diarrhoea, constipation, nausea or vomiting; fainting, dizziness or light-headedness in the past; kidney problems; moderate to severe liver problems; numbness, tingling, or pain in the hands or feet (neuropathy) in the past; heart or blood pressure problems; shortness of breath or cough; seizures; shingles (localized including around the eyes or spread across the body); symptoms of tumor lysis syndrome such as muscle cramping, muscle weakness, confusion, visual loss or disturbances and shortness of breath; memory loss, trouble thinking, difficulty with walking or loss of vision (these may be signs of a serious brain infection and further testing and follow-up may be suggested).
The patient will have to take regular blood tests before and during the treatment with PMS-BORTEZOMIB, to check the blood cell counts regularly.
The package leaflets of all medicinal products to be taken in combination with PMS-BORTEZOMIB must be read for information related to these medicines before starting treatment with PMS-BORTEZOMIB. When thalidomide is used, particular attention to pregnancy testing and prevention requirements is needed (see Use in Pregnancy & Lactation).
Driving and using machines: PMS-BORTEZOMIB might cause tiredness, dizziness, fainting, or blurred vision. Patients must be advised not to drive or operate tools or machines if they experience such side effects; even if they do not, they should still be cautious.
Use in Children: PMS-BORTEZOMIB should not be used in children and adolescents because it is not known how the medicine will affect them.