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Symptoms: Single oral doses of metronidazole up to 15 g have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting and ataxia.
Oral metronidazole has been studied as a radiation sensitiser in the treatment of malignant tumours. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.
Treatment: There is no specific antidote for metronidazole overdose, therefore, management of the patient should consist of symptomatic and supportive therapy.
