Pentaglobin Dosage/Direction for Use

Posology: The dosage is dependent on the patient's immune status and on the severity of the disease. The following dosage suggestions may be used as reference: Neonates and infants: 5 ml (0.25 g)/kg body weight daily on three consecutive days. Further infusions may be required depending on the clinical course.
Children and adults: a) Therapy of severe bacterial infections: 5 ml (0.25 g)/kg body weight daily on three consecutive days. Further infusions may be required depending on the clinical course.
b) Immunoglobulin substitution in immunocompromized patients and in severe secondary antibody deficiency syndrome patients: 3 - 5 ml (0.15 - 0.25 g)/kg body weight. Repetition at weekly intervals, if necessary.
Pentaglobin should be warmed to room or body temperature before use.
Pentaglobin should be infused intravenously at the following rates: In neonates and infants: 1.7 ml/kg body weight/hour by infusion pump.
In children and adults: 0.4 ml/kg body weight/hour.
Alternatively: the first 100 ml at 0.4 ml/kg body weight/hour then 0.2 ml/kg body weight/hour continuously until 15 ml/kg body weight is reached within 72 hours. (See Table 1.)

Click on icon to see table/diagram/image

Method of administration: Intravenous use.