Toxicity is extremely rare following administration of recommended dose. Nevertheless, massive overdose of Acetaminophen may adversely affect the liver of some people and signs or symptoms of overdose may be delayed for up to one week following ingestion. Nevertheless, liver damage is largely reversible if the patient is treated early, thus prompt medical attention is essential in all cases of suspected overdose even if there is no sign or symptom. Administration of N-acetylcysteine or Methionine may be required. Acetaminophen overdose may cause liver failure. Overdose of caffeine may result in epigastric pain, vomiting, diuresis, tachycardia or cardiac arrhythmia. CNS stimulation (insomnia, restlessness, excitement, agitation, jitteriness, tremors and convulsions). It must be noted that for clinically significant symptoms of caffeine overdose to occur with this product, the amount ingested would be associated with serious Acetaminophen-related liver toxicity.
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