P-Fen Drug Interactions

NSAIDs may enhance the effects of anti-coagulants, such as warfarin.
Diuretics can increase the risk of nephrotoxicity of NSAIDs.
Concomitant use with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding.
Combination use with anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs) increase risk of gastrointestinal bleeding.
Combination use with cardiac glycosides, NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels.
Increase risk of nephrotoxicity when use with ciclosporin.
NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone.
Possible increased risk of nephrotoxicity when NSAIDs are given with tacrolimus.
Increased risk of haematological toxicity when NSAIDs are given with zidovudine. There is evidence of an increased risk of haemarthroses and haematoma in HIV (+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen.