Nutryelt Mechanism of Action

Pharmacotherapeutic group: Electrolyte solutions. ATC code: B05XA31.
Pharmacology: Pharmacodynamics: NUTRYELT is a balanced solution composed of nine essential trace elements, which are necessary to maintain the metabolic equilibrium.
Trace elements are normally derived from a balanced diet, but the need increases in cases of insufficient supply or abnormal loss, hypercatabolism (surgery, major trauma, burns), and in cases of poor absorption (short bowel disease or Crohn's disease).
During artificial nutrition, the supply of trace elements is necessary because a deficiency of any one of them can generate important metabolic and clinical disturbances.
Pharmacokinetics: The various pathways of trace element metabolism can be summarised as follows: Blood transport by proteins: albumin (Mn, Cu, Zn, Se), transferrin (Fe, Cr), ceruloplasmin (Cu), selenomethionine (Se), or non-protein carriers (F, I, Mo).
Storage involving specific proteins: ferritin (Fe), thyroid hormones (I), selenoproteins (Se), or non-specific proteins: metallothioneins (Cu, Zn, Mn, Mo) or fluoroapatite (F).
Elimination: The cationic trace elements (Fe, Cu, Mn, Zn) are eliminated mainly through biliary excretion. The anionic trace elements (I, F) and some oxygenated forms of minerals (Mo, Se, Cr) are primarily excreted in the urine.
Elimination through the lungs and the skin is possible.
Toxicology: Preclinical safety data: Since trace element solutions for intravenous injection are well-known products that have been used for medical purposes for many decades, no preclinical studies have been specifically performed with NUTRYELT.