IV bolus inj Haemophilia A or B w/ inhibitors or expected to have a high anamnestic response Initially 90 mcg/kg, 2-3 hr dose interval to obtain haemostasis, then may be increased to every 4, 6, 8 or 12 hr, if continued therapy is needed.
Mild to moderate bleeding episodes (including home therapy) 2-3 inj of 90 mcg/kg every 3 hr; or single 270 mcg/kg. Max home therapy duration: 24 hr.
Serious bleeding episodes Initially 90 mcg/kg every 2 hr, can be increased to every 3 hr for 1-2 days. Thereafter, can be increased to every 4, 6, 8 or 12 hr. Major bleeding episode may be treated for 2-3 wk.
Invasive procedure/surgery Initially 90 mcg/kg, repeated after 2 hr, then at 2-3 hr intervals for the 1st 24-48 hr. Dose should be continued at 2-4 hr intervals for 6-7 days in major surgery; may be increased to 6-8 hr for another 2 wk. Patients undergoing major surgery may be treated for up to 2-3 wk.
Acquired haemophilia Initially 90 mcg/kg every 2-3 hr, may be increased to every 4, 6, 8 or 12 hr once haemostasis has been achieved.
Factor VII deficiency 15-30 mcg/kg every 4-6 hr.
Glanzmann's thrombasthenia At least 3 doses of 90 mcg (80-120 mcg)/kg every 2 hr (1.5-2.5 hr).
Severe postpartum haemorrhage 60-90 mcg/kg, a 2nd dose can be administered after 30 min in case of insufficient haemostatic response.
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