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Concomitant administration of vitamin A and other retinoids must be avoided because of the risk of hypervitaminosis A.
Low dose progesterone-only products (minipills) may be an inadequate method of contraception during Neotigason, see Use in Pregnancy & Lactation. Interactions with combined estrogen/progestogen oral contraceptives have not been observed.
Investigations into the effect of Neotigason on the protein binding of anticoagulants of the coumarin type (warfarin) revealed no interaction.
If Neotigason is given concurrently with phenytoin, it must be remembered that Neotigason partially reduces phenytoin's protein binding.
Methotrexate, tetracyclines: see Contraindications.
Further interactions between Neotigason and other substances (e.g. digoxin, cimetidine, combined estrogen/progestogen oral contraceptives) have not been observed so far.
