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Indications and Dosage
Ophthalmic
Superficial ocular infections Adult: Neomycin 1.75 mg, polymyxin B 10,000 units, and gramicidin 0.025 mg per mL eye drop solution
Instil 1-2 drops into the affected eye(s) 4 hourly for 7-10 days, may increase to 2 drops hourly in severe cases. |
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What are the brands available for Neomycin + Polymyxin B + Gramicidin in Hong Kong?
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Contraindications
Hypersensitivity to neomycin, polymyxin B or gramicidin.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Significant: Sensitisation (e.g. failure to heal, conjunctival and eyelid itching, reddening, and oedema), ocular effects (e.g. glaucoma, defects in visual acuity, posterior subcapsular cataract formation, secondary ocular infections) particularly during prolonged use, overgrowth of nonsusceptible organisms including fungi (long-term use).
Eye disorders: Local irritation. Immune system disorders: Hypersensitivity reactions. Rarely, anaphylaxis. |
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Ophth: C
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Patient Counseling Information
Remove contact lenses prior to administration and wait for at least 15 minutes before reinserting the lenses.
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Monitoring Parameters
Assess for signs and symptoms of sensitisation periodically (particularly in long-term use).
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Action
Description:
Mechanism of Action: Neomycin, an aminoglycoside antibiotic, binds with the ribosomal RNA of susceptible bacteria thus inhibiting the protein synthesis and resulting in the misreading of the bacterial genetic code. Polymyxin B is a polymyxin antibiotic. It binds to cytoplasmic membrane phospholipids of the susceptible bacteria, which alters the membrane permeability, thereby causing a leakage of essential metabolites. Gramicidin is bactericidal against a range of Gram-positive bacteria. It binds to bacterial cell membrane forming channels through the normal lipid bilayer, thereby increasing its permeability to inorganic cations. |
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Storage
Store between 15-25°C. Protect from light.
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MIMS Class
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ATC Classification
S01AA30 - combinations of different antibiotics ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
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References
Anon. Neomycin Sulfate (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 20/08/2024. Anon. Polymyxin B. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 20/08/2024. Brayfield A, Cadart C (eds). Gramicidin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/08/2024. Brayfield A, Cadart C (eds). Neomycin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/08/2024. Brayfield A, Cadart C (eds). Polymyxin B Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/08/2024. Neomycin Sulfate, Polymyxin B Sulfate and Gramicidin Solution/Drops (Bausch & Lomb Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/08/2024. Neomycin, Polymyxin B, and Gramicidin. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 20/08/2024. Neomycin; Polymyxin B; Gramicidin. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 20/08/2024. Polymyxin B. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 20/08/2024.
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