Adult: Each mL of eye drops solution contains naphazoline hydrochloride 0.5 mg and antazoline phosphate 5 mg
For temporary symptomatic relief of itching, redness, tearing and swelling associated with ocular allergies: Instil 1-2 drops into the affected eye(s) 3-4 hourly (or less frequently).
Each mL of eye drops solution contains naphazoline hydrochloride 1 mg and antazoline hydrochloride 2.5 mg
For temporary symptomatic relief of itching, redness, tearing and swelling associated with ocular allergies: Instil 1-2 drops into the affected eye(s) up to 4 times daily, as required. Dosage and treatment recommendations may vary among countries and between individual products (refer to specific product guidelines).
Contraindications
Narrow-angle glaucoma.
Special Precautions
Patient with CV disease or hypertension, diabetes, hyperthyroidism. Avoid prolonged or excessive use. Pregnancy and lactation.
Adverse Reactions
Significant: May cause hypertension. Cardiac disorders: Cardiac irregularities, irregular heart rate. Eye disorders: Mydriasis with increased IOP. Gastrointestinal disorders: Nausea. Metabolism and nutrition disorders: Hyperglycaemia. Nervous system disorders: Headache, dizziness, drowsiness.
Patient Counseling Information
This drug may cause temporary blurred vision, if affected, do not drive or operate machinery. Discontinue use and consult your doctor if you experience pain, vision changes, worsening of your condition, or persistent eye redness or irritation that lasts more than 48 hours. Remove contact lenses before administration and reinsert after 15 minutes.
Drug Interactions
Naphazoline: May result in enhanced pressor effects with maprotiline or TCAs. May increase the risk of severe hypertensive crisis with MAOIs.
Action
Description: Overview: Naphazoline, an imidazoline derivative sympathomimetic, is a vasoconstrictor with marked α-adrenergic activity.
Antazoline, an ethylenediamine derivative, is an antihistamine. Mechanism of Action: Naphazoline acts by stimulating the α-adrenergic receptors located in the arterioles of the conjunctiva, resulting in vasoconstriction.
Antazoline inhibits the effects of histamine on conjunctival epithelial cells. Onset: Naphazoline: Local vasoconstriction: Within 10 minutes. Duration: Naphazoline: Local vasoconstriction: 2-6 hours. Pharmacokinetics: Absorption: Naphazoline: Systemic absorption may occur.
Chemical Structure
Naphazoline Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4436, Naphazoline. https://pubchem.ncbi.nlm.nih.gov/compound/Naphazoline. Accessed Feb. 24, 2026.
Antazoline Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2200, Antazoline. https://pubchem.ncbi.nlm.nih.gov/compound/Antazoline. Accessed Feb. 24, 2026.
S01GA51 - naphazoline, combinations ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
References
Brayfield A, Cadart C (eds). Antazoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/12/2025.Brayfield A, Cadart C (eds). Naphazoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/12/2025.Naphazoline (Ophthalmic). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 12/12/2025.Naphazoline and Antazoline (Ophthalmic). UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 12/12/2025.Naphazoline Hydrochloride. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 12/12/2025.Vasacon-A Sterile Eye Drops (Cendo). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 15/12/2025.
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