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Pharmacology: Pharmacodynamics: Mupirocin is a topical antibacterial agent, active against those organisms responsible for the majority of skin infections eg, Staphylococcus aureus including methicillin-resistant strains, other staphylococci and streptococci. It is also active against certain gram-negative pathogens eg, Haemophilus influenzae.
Pharmacokinetics: Absorption: Mupirocin penetrates intact human skin but the rate of systemic absorption appears to be low.
Excretion: Systemically absorbed mupirocin is rapidly metabolised to the inactive metabolite monic acid and quickly excreted by the kidneys.
