Hypersensitivity to tenecteplase, to any of the excipients (L-arginine, phosphoric acid, polysorbate 20), or to gentamicin. Significant bleeding disorder either at present or w/in the past 6 mth; patients receiving effective oral anticoagulant treatment eg, warfarin Na (INR >1.3); any history of CNS damage (ie, neoplasm, aneurysm, intracranial or spinal surgery); known haemorrhagic diathesis; severe uncontrolled HTN; major surgery, biopsy of a parenchymal organ, or significant trauma w/in the past 2 mth (including any trauma associated w/ current AMI); recent trauma to the head or cranium; prolonged CPR (>2 min) w/in the past 2 wk; acute pericarditis &/or subacute bacterial endocarditis; acute pancreatitis; severe hepatic dysfunction, including hepatic failure, cirrhosis, portal HTN (oesophageal varices) & active hepatitis; active peptic ulceration; arterial aneurysm & known arterial/venous malformation; neoplasm w/ increased bleeding risk; any known history of haemorrhagic stroke or stroke of unknown origin; known history of ischaemic stroke or transient ischaemic attack in the preceding 6 mth; dementia.
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