Loceryl Mechanism of Action

Topical antifungal.
Pharmacology: Amorolfine belongs to a new chemical class of antifungal substances. Its fungicidal and fungistatic effect is based on an alteration of the fungal cell membrane targeted primarily on sterol biosynthesis. The ergosterol content is reduced, and at the same time unusual, sterically nonplanar sterols accumulate.
Microbiology: Amorolfine has a broad antifungal spectrum in vitro. It is effective against:
Dermatophytes: Trichophyton, Microsporum, Epidermophyton.
Yeasts: Candida.
Moulds: Alternaria, Scopulariopsis, Hendersonula.
With the exception of Actinomyces, bacteria are not sensitive to amorolfine.
Pharmacokinetics: Amorolfine penetrates into and diffuses through the nail plate and is thus able to eradicate poorly accessible fungi in the nail bed. Systemic absorption of amorolfine is very low with this type of application, since the drug plasma concentration remains below the sensitivity limit of the analytical assay even after 1 year of use.