Lipistad Dosage/Direction for Use

Administration: Atorvastatin is administered orally once daily, at any time of the day, without regard to meals.
The patient should be placed on a standard cholesterol-lowering diet before initiation of atorvastatin therapy and should remain on this diet during treatment with the drug.
The drug should be initiated with a lowest effective dose, thereafter dosage of atorvastatin may be adjusted, if necessary, according to individual requirements and response by increased at intervals of no less than 4 weeks. Patients should be fully advised about adverse reactions, especially myogenic reactions.
Dosage: The usual initial oral dosage of atorvastatin in adults for the management of primary hypercholesterolemia (heterozygous familial or nonfamilial) and mixed dyslipidemia is 10 or 20 mg once daily. Patients requiring reductions in LDL-cholesterol of more than 45% to achieve their goal may be started on an atorvastatin dosage of 40 mg daily. The usual maintenance dosage of atorvastatin in adults is 10 - 80 mg once daily.
The recommended initial dosage of atorvastatin for treatment of heterozygous familial hypercholesterolemia in boys and postmenarchal girls 10 years of age or older is 10 mg once daily. The maximum recommended dosage is 20 mg daily.
The usual oral dosage of atorvastatin for the management of homozygous familial hypercholesterolemia is 10 - 80 mg once daily. The drug may be used as an adjunct to other lipid-lowering therapies (e.g., plasma LDL-apheresis) or when such therapies are not available.
The dosage of atorvastatin should be adjusted at intervals of no less than 4 weeks until the desired effect on lipoprotein concentrations is observed. Reduction of atorvastatin dosage should be considered in patients whose serum cholesterol concentrations fall below the desired target range.
Renal impairment: Because atorvastatin does not undergo substantial renal excretion, dosage modification in patients with renal impairment is not necessary.