Klacid Overdosage

Film-coated tablet and Granules for oral suspension: Reports indicate that the ingestion of large amounts of clarithromycin can be expected to produce gastro-intestinal symptoms. One patient who had a history of bipolar disorder ingested 8 grams of clarithromycin and showed altered mental status, paranoid behaviour, hypokalaemia and hypoxaemia.
Adverse reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures. As with other macrolides, clarithromycin serum levels are not expected to be appreciably affected by haemodialysis or peritoneal dialysis.
Modified-release tablet: An overdose of clarithromycin generally produces gastrointestinal symptoms.
Gastric lavage should be considered within the first two hours of ingestion. Clarithromycin cannot undergo adequate haemodialysis or peritoneal dialysis. Absorption-preventing measures are recommended.
One patient who had a history of bipolar disorder ingested 8 g of clarithromycin in a suicide attempt which resulted in paranoid behavior and altered mental status, as well as hypokalemia and mild hypoxemia.