Kincef

Cefuroxime (as axetil).

Each tablet contains: Cefuroxime axetil 300.72 mg (equivalent to cefuroxime 250 mg).

Kincef is indicated for the treatment of the following infections in adults and children from the age of 3 months: Acute streptococcal tonsillitis and pharyngitis; Acute bacterial sinusitis; Acute otitis media; Acute exacerbations of chronic bronchitis; Cystitis; Pyelonephritis; Uncomplicated skin and soft tissue infections; Early Lyme disease.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Posology: The usual course of therapy is seven days (may range from five to ten days). (See Tables 1 and 2.)

Click on icon to see table/diagram/image


Click on icon to see table/diagram/image

Consider other source for dosage less than 250 mg.
There is no experience of using Kincef in children under the age of 3 months.
Cefuroxime axetil tablets and cefuroxime axetil granules for oral suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Renal impairment: The safety and efficacy of cefuroxime axetil in patients with renal failure have not been established.
Cefuroxime is primarily excreted by the kidneys. In patients with markedly impaired renal function, it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion. Cefuroxime is effectively removed by dialysis. (See Table 3.)

Click on icon to see table/diagram/image

Hepatic impairment: There are no data available for patients with hepatic impairment. Since cefuroxime is primarily eliminated by the kidney, the presence of hepatic dysfunction is expected to have no effect on the pharmacokinetics of cefuroxime.
Method of administration: Oral use.
Kincef tablets should be taken after food for optimum absorption.
Kincef tablets should not be crushed and are therefore unsuitable for treatment of patients who cannot swallow tablets. In children, cefuroxime axetil oral suspension may be used.
Depending on the dosage, there are other sources of cefuroxime axetil available.

Cephalosporins

J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

A