Sign Out
In healthy volunteers, single doses of up to 40 mg/kg per day with the tablet for oral suspension formulation were tolerated.
Early signs of acute overdose are digestive effects such as abdominal pain, diarrhea, nausea and vomiting. Hepatic and renal disorders have been reported, including cases of liver enzyme and creatinine increased with recovery after treatment discontinuation. An erroneously administered single dose of 90 mg/kg led to Fanconi syndrome which resolved after treatment.
There is no specific antidote for deferasirox. Standard procedures for management of overdose (e.g. induction of emesis or gastric lavage) may be indicated as well as symptomatic treatment, as medically appropriate.
In one pediatric case, a dose of 2-3 times the prescribed dose for six days resulted in acute renal failure requiring hemofiltration and acute liver injury/failure, which were reversible with intensive care support.
For management of a suspected drug overdose, contact the regional poison control centre.
Continue with Google