Itrazol

Itraconazole

Treatment of yeast infections of the mouth, throat or gullet in patients w/ poor immune system. Prevention of certain fungal infections in patients w/ poor immune system due to a major blood disorder or bone marrow transplantation.

Treatment of yeast infections of the mouth, throat or gullet 20 mL/day either once daily or in 2 divided doses during the day, for 1 wk. Patients treated w/ another antifungal but infections have still not cleared 10-20 mL bd for 2 wk, may be continued for additional 2 wk if infection still persists. For patients on 400 mg daily, treatment should be limited to 14 days. Prevention of fungal infections 5 mg/kg in 2 divided doses.

Should be taken on an empty stomach.

Hypersensitivity. Concomitant use w/ terfenadine, astemizole, mizolastine; bepridil; nisoldipine; cisapride; midazolam (oral), triazolam; lovastatin, simvastatin, atorvastatin; pimozide, sertindole; levacetylmethadol; dihydroergotamine, ergotamine, eletriptan; ergometrine (ergonovine), methylergometrine (methylergonovine); quinidine, dofetilide. Pregnancy.

Unusual tingling sensation, numbness or weakness in hands or feet; any hearing loss symptoms; allergic reaction to any other antifungals; heart problem including CHF; liver problem eg, jaundice; kidney disorder. Discontinue treatment in case of any signs & symptoms of severe liver problems. Fructose intolerance. May affect ability to drive or use machines. Do not take Itrazol if breastfeeding.

Symptoms resembling heart failure eg, shortness of breath, unexpected wt gain, swelling of the legs, unusual fatigue (tiredness), repeated waking at night; tingling sensation, sensitivity to light, numbness or weakness in the limbs; blurred vision/double vision, ringing in the ears, inability to control urine or increased need to urinate; hearing loss symptoms. Headache; stomachache, nausea, vomiting, diarrhoea, unpleasant taste; hepatic enzyme increased; rash; fever or high temp; shortness of breath.

Contraindicated w/ terfenadine, astemizole, mizolastine; bepridil; nisoldipine; cisapride; midazolam (oral), triazolam; lovastatin, simvastatin, atorvastatin; pimozide, sertindole; levacetylmethadol; dihydroergotamine, ergotamine, eletriptan; ergometrine (ergonovine), methylergometrine (methylergonovine); quinidine, dofetilide. Do not use Itrazol oral soln w/in 2 wk of taking rifampicin, rifabutin, isoniazid; phenytoin, carbamazepine, phenobarb; St. John's wort. Dose adjustments may be needed w/ clarithromycin, erythromycin; digoxin, disopyramide, Ca channel-blockers eg, dihydropyridines, verapamil, cilostazol; anticoagulants eg, warfarin; methylprednisolone, budesonide, fluticasone, dexamethasone; ciclosporin, tacrolimus, rapamycin (sirolimus); anti-HIV eg, ritonavir, indinavir, saquinavir; anti-cancer eg, busulphan, docetaxel, trimetrexate, vinca alkaloids; alfentanil, fentanyl; buspirone, alprazolam, brotizolam, midazolam (inj); reboxetine; loperamide; ebastine; halofantrine; repaglinide.

Antifungals

J02AC02 - itraconazole ; Belongs to the class of triazole and tetrazole derivatives. Used in the systemic treatment of mycotic infections.

P₁S₁S₃