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DO NOT MIX OR CO-INFUSE INVANZ WITH OTHER MEDICATIONS. DO NOT USE DILUENTS CONTAINING DEXTROSE (α-D-GLUCOSE).
INVANZ may be administered by intravenous infusion for up to 14 days or intramuscular injection for up to 7 days. When administered intravenously, INVANZ should be infused over a period of 30 minutes. Intramuscular administration of INVANZ may be used as an alternative to intravenous administration in the treatment of those infections for which intramuscular therapy is appropriate.
Treatment Regimen: 13 years of age and older: The dose of INVANZ in patients 13 years of age and older is 1 gram (g) given once a day [see Pharmacology: Pharmacokinetics under Actions].
3 months to 12 years of age: The dose of INVANZ in patients 3 months to 12 years of age is 15 mg/kg twice daily (not to exceed 1 g/day).
Table 4 presents treatment guidelines for INVANZ. (See Table 4.)
Click on icon to see table/diagram/imageProphylactic Regimen in Adults: Table 5 presents prophylaxis guidelines for INVANZ. (See Table 5.)
Click on icon to see table/diagram/imagePatients with Renal Impairment: INVANZ may be used for the treatment of infections in adult patients with renal impairment. In patients whose creatinine clearance is >30 mL/min/1.73 m2, no dosage adjustment is necessary. Adult patients with severe renal impairment (creatinine clearance ≤30 mL/min/1.73 m2) and end-stage renal disease (creatinine clearance ≤10 mL/min/1.73 m2) should receive 500 mg daily. A supplementary dose of 150 mg is recommended if ertapenem is administered within 6 hours prior to hemodialysis. There are no data in pediatric patients with renal impairment.
Patients on Hemodialysis: When adult patients on hemodialysis are given the recommended daily dose of 500 mg of INVANZ within 6 hours prior to hemodialysis, a supplementary dose of 150 mg is recommended following the hemodialysis session. If INVANZ is given at least 6 hours prior to hemodialysis, no supplementary dose is needed. There are no data in patients undergoing peritoneal dialysis or hemofiltration. There are no data in pediatric patients on hemodialysis.
When only the serum creatinine is available, the following formula may be used to estimate creatinine clearance. The serum creatinine should represent a steady state of renal function. (See equation.)
Click on icon to see table/diagram/imagePatients with Hepatic Impairment: No dose adjustment recommendations can be made in patients with hepatic impairment [see Patients with Hepatic Impairment under Precautions; Pharmacology: Pharmacokinetics under Actions].
