HyperRho-D (Rho(D) Immune Globulin-Human) (SD Viral Inactivated) Special Precautions

A large fetomaternal hemorrhage late in pregnancy or following delivery may cause a weak mixed positive D test result. If there is any doubt about the mother's Rh type, she should be given Rho(D) immune globulin (human). A screening test to detect total red blood cells may be helpful in such cases.
If >15 mL of D-positive fetal red blood cells are present in the mother's circulation, more than a single dose of Bayrho-D (Rho(D) Immune Globulin-Human) (SD Viral Inactivated) full dose is required. Failure to recognize this may result in the administration of an inadequate dose.
Although systemic reactions to human immunoglobulin preparations are rare, epinephrine should be available for treatment of acute anaphylactic reactions.
Use in pregnancy: Pregnancy Category C: Animal reproduction studies have not been conducted with Bayrho-D (Rho(D) Immune Globulin-Human) (SD Viral Inactivated). It is also not known whether it can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Bayrho-D (Rho(D) Immune Globulin-Human) (SD Viral Inactivated) full dose should be given to a pregnant woman only if clearly needed.
Use in children: Safety and effectiveness in the pediatric population have not been established.