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Drug-Drug interactions: Concurrent administration of nitroglycerin and acetylcysteine has been shown to cause significant hypotension and enhance temporal artery dilation. If concurrent nitroglycerin and acetylcysteine therapy is necessary, patients should be monitored for hypotension, which can be severe, and warned of the possibility of headaches.
Reports of an inactivation of antibiotics resulting from acetylcysteine so far only relate to in-vitro tests in which the relevant substances were mixed directly. Therefore, dissolution of acetylcysteine formulations concomitantly with other drugs is not recommended.
Paediatric population: Interaction studies have only been performed in adults.
Drug-Lab modifications: Acetylcysteine may cause interference with colorimetric assay method for salicylate measurement. Acetylcysteine may interfere with urine ketone test.
