Hepatitis A and Hepatitis B vaccine


Generic Medicine Info
Indications and Dosage
Intramuscular
Active immunisation against hepatitis A, Active immunisation against hepatitis B
Adult: As susp for inj containing inactivated hepatitis A virus 720 ELISA units and recombinant hepatitis B surface antigen 20 mcg per mL: Primary immunisation: 1 mL given at 0, 1, and 6 months for a total of 3 doses. Alternatively, under exceptional circumstances, an accelerated dosing series of 1 mL given at Days 0, 7, and 21, followed by a booster dose 12 months after the initial dose for a total of 4 doses. Doses are administered via IM inj. In patients with thrombocytopenia or bleeding disorders, some preparations may be given via SC inj but immune response may be reduced. Recommendations may vary between individual products or local immunisation guidelines (refer to specific local guidelines).
Child: As susp for inj containing inactivated hepatitis A virus 360 ELISA units and recombinant hepatitis B surface antigen 10 mcg per 0.5 mL: 1-15 years Primary immunisation: 0.5 mL given at 0, 1, and 6 months for a total of 3 doses. As susp for inj containing inactivated hepatitis A virus 720 ELISA units and recombinant hepatitis B surface antigen 20 mcg per mL: 1-15 years Primary immunisation: 1 mL via IM inj given at 0 and between 6-12 months after the initial dose for a total of 2 doses; ≥16 years Same as adult dose. In patients with thrombocytopenia or bleeding disorders, some preparations may be given via SC inj but immune response may be reduced. Recommendations may vary between individual products or local immunisation guidelines (refer to specific local guidelines).
What are the brands available for Hepatitis A and Hepatitis B vaccine in Hong Kong?
Contraindications
Hypersensitivity.
Special Precautions
Patient with bleeding disorders including thrombocytopenia and those receiving anticoagulant therapy. Not indicated for postexposure prophylaxis for hepatitis A and B (e.g. needle stick injury). Defer vaccination in patients with moderate to severe acute illness (with or without fever) or during periods of severe immunosuppression (e.g. patients receiving chemotherapy, radiation or other immunosuppressive treatments including high-dose corticosteroids). Dialysis patients. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Syncope, hypersensitivity reactions (e.g. anaphylaxis), shoulder injury (e.g. shoulder bursitis, tendinopathy), bleeding or haematoma.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea; abdominal pain (children).
General disorders and administration site conditions: Inj site reactions (e.g. pain, redness, pruritus, bruising, burning sensation, swelling), fatigue, malaise, fever.
Infections and infestations: URTI.
Metabolism and nutrition disorders: Loss of appetite (children).
Musculoskeletal and connective tissue disorders: Arthralgia, myalgia.
Nervous system disorders: Headache, dizziness, drowsiness.
Psychiatric disorders: Irritability (children).
Monitoring Parameters
Monitor for hypersensitivity and syncope within 15 minutes of administration.
Drug Interactions
Reduced immune response with immunosuppressants. Risk for bleeding or haematoma with anticoagulants.
Lab Interference
May interfere with serum HBsAg detection test result.
Action
Description:
Mechanism of Action: Hepatitis A and hepatitis B vaccine is derived from inactivated hepatitis A virus (HAV) and recombinant hepatitis B surface antigen (HbsAg) protein which provides active immunisation against HAV and hepatitis B virus (HBV) by inducing specific anti-HAV and anti-hepatitis B surface antibodies.
Onset: Seroconversion for antibodies against HAV and HBV: 1 month after completion of 3-dose series.
Duration: HAV and HBV seropositivity: 15 years (adults); 10 years (children).
Storage
Store between 2-8°C. Do not freeze. Protect from light.
MIMS Class
Vaccines, Antisera & Immunologicals
References
Brayfield A, Cadart C (eds). Hepatitis A and B Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2024.

GlaxoSmithKline NZ Limited. Twinrix, Twinrix Junior Suspension for Injection data sheet 20 February 2023. Medsafe. http://www.medsafe.govt.nz. Accessed 05/07/2024.

Hepatitis A and Hepatitis B Recombinant Vaccine. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/07/2024.

Joint Formulary Committee. Hepatitis A and B Vaccine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2024.

Twinrix Adult, Suspension for Injection in Pre-filled Syringe (GlaxoSmithKline UK Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/07/2024.

Twinrix Paediatric, Suspension for Injection in Pre-filled Syringe (GlaxoSmithKline UK Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/07/2024.

Twinrix Suspension for Injection (GlaxoSmithKline Pharmaceuticals Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 05/07/2024.

Twinrix Vaccine Injection, Suspension (GlaxoSmithKline Biologicals SA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 05/07/2024.

Disclaimer: This information is independently developed by MIMS based on Hepatitis A and Hepatitis B vaccine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com
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