Gentamicin Sulph BP - Panpharma Dosage/Direction for Use

Posology: Adults: The daily recommended dose in adults with normal renal function is 3-6 mg/kg body weight per day as one (preferred) up to two single doses.
Serious infections: In life-threatening infections the frequency of dosage may need to be increased to 6-hourly and the quantity of each dose may also be increased at the discretion of the clinician up to a total dosage of 5 mg/kg in 24 hours. In such cases it is advisable to monitor gentamicin serum levels.
If renal function is not impaired, 160 mg once daily may be used in some cases.
Renal impairment: In cases of impaired renal function a reduction in dosage frequency is recommended. The following table is a guide to recommended dosage schedules: See Table 1.

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Paediatric population: The daily recommended dose in children and adolescents with normal renal function is 3-6 mg/kg body weight per day as one (preferred) up to two single doses.
The daily dose in infants after the first month of life is 4.5-7.5 mg/kg body weight per day as one (preferred) up to two single doses.
The daily dose in newborns is 4-7 mg/kg body weight per day. Due to the longer half-life, newborns are given the required daily dose in one single dose.
Method of administration: Gentamicin is normally administered intramuscularly but may be given intravenously as a slow intravenous injection over at least 3 minutes or short infusion if required. Gentamicin should not be given as a slow infusion or mixed with other drugs before use (see Incompatibilities under Cautions for Usage).
Monitoring advice: Serum concentration monitoring of gentamicin is recommended, especially in elderly, in newborns and in patients with impaired renal function. Samples are taken at the end of a dosing interval (trough level). Trough levels should not exceed 2 μg/ml administering gentamicin twice daily and 1 μg/ml for a once daily dose.
Prolonged use should be avoided and whenever possible the treatment should not exceed 7 days.
Caution is advised in significant obesity as gentamicin is poorly distributed into fatty tissue. The dosage calculation should be based on an estimate of lean body weight. Serum levels should be monitored closely and the dose possibly adjusted (see Precautions).