Gemstain

Iodine, potassium iodide.

Each 100 mL contains: Iodine (USP) 5.0 g; Potassium Iodine (USP) (7.64 g as Iodine) 10.0 g.

For use in the pre-operative management of hyperthyroidism.

Oral.
Dose: Adults, children and the elderly: 0.1 - 0.3 ml well diluted in milk or water.
Dosage schedule: To be taken three times a day for six days.

Symptoms of acute poisoning from ingestion of iodine include a disagreeable metallic taste, vomiting, abdominal pain and diarrhea may occur. Renal failure may occur 1-3 days later. Death may be caused by circulatory failure, swelling of the epiglottis causing asphyxia, aspiration, pneumonia or pulmonary oedema. Oesophageal stricture may occur if the patient survives the acute stage. The fatal dose of iodine is 2 to 3 g.
Symptomatic treatment for allergic reactions and iodism may be required, although symptoms usually subside rapidly when administration of iodine or iodide is stopped. In acute poisoning copious draughts of milk and starch mucilage should be given. If there is no oesophageal damage the stomach may be emptied by aspiration and lavage with dilute starch mucilage or a 1% solution of sodium thiosulphate. Use of gastric lavage with activated charcoal has also been suggested. Electrolyte and water losses should be replaced and the circulation should be maintained. Pethidine or morphine sulphate may be given for pain, under medical supervision. A tracheotomy may become necessary.

Patients hypersensitive to iodine or iodides.
Patients in pregnancy and lactation.

Use with caution in children.
Should not be used for long-term treatment.

Not to be used during pregnancy and lactation. Iodides cross the placenta and are excreted in breast milk.
There is a possibility of goiter in infants of mothers taking iodides.

This drug may cause allergic reactions, including urticarial, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy and eosinophilia, coryza-like symptoms, headache, lachrymation, conjunctivitis, laryngitis, bronchitis, and pain in the salivary glands.
In addition to the previously mentioned, use may lead to adverse effects on the mouth such as metallic taste, increased salivation, burning or pain.
Swelling and inflammation of the throat, acneiform skin disorders, depression, insomnia, impotence and diarrhea (which may be bloody) can also result.

Administration of this drug may interfere with tests of thyroid function.

Stored in a tightly closed and light-shield container at room temperature (below 25°C).
Keep stored off the light.
Do not change the container.

Antithyroid Agents

H03CA - Iodine therapy ; Used in the management of thyroid diseases.

NP