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In a study of 15 healthy subjects administered digoxin daily to steady state, a single FORTEO dose did not alter the cardiac effect of digoxin. However, sporadic case reports have suggested that hypercalcaemia may predispose patients to digitalis toxicity. Because FORTEO transiently increases serum calcium, FORTEO should be used with caution in patients taking digitalis.
FORTEO has been evaluated in pharmacodynamic interaction studies with hydrochlorothiazide. No clinically significant interactions were noted.
Co-administration of raloxifene or hormone replacement therapy with FORTEO did not alter the effects of FORTEO on serum or urine calcium or on clinical adverse events.
