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Pharmacology: Pharmacodynamics: Fusidic acid and its salts exert antibacterial activity against most Gram positive organisms; in particular, they are effective against pathogenic Staphylococci, including the penicillinase-producing strains. It has slight or no activity against Gram negative organisms and fungi.
Pharmacokinetics: Fusidic acid and its salts are widely distributed into tissues and body fluids, including bone, pus, and synovial fluid; it penetrates cerebral abscesses but do not enter cerebrospinal fluid in appreciable amounts.They have been found in the foetal circulation and in breast milk. About 95% or more of Fusidic acid or Sodium fusidate in the circulation is bound to plasma protein. Fusidic acid or Sodium fusidate is excreted in the bile, almost entirely as metabolites, some of which have weak antimicrobial activity. About 2% appears unchanged in the faeces. Little is excreted in the urine or removed by haemodialysis.
