FluMist Trivalent Drug Interactions

Aspirin Therapy: Do not administer FluMist Trivalent to children and adolescents through 17 years of age who are receiving aspirin therapy or aspirin-containing therapy because of the association of Reye's syndrome with aspirin and wild-type influenza [see Concomitant Aspirin Therapy and Reye's Syndrome in Children and Adolescents under Contraindications]. Avoid aspirin-containing therapy in these age groups during the first 4 weeks after vaccination with FluMist Trivalent unless clearly needed.
Antiviral Agents Against Influenza A and/or B: Antiviral drugs that are active against influenza A and/or B viruses may reduce the effectiveness of FluMist Trivalent if administered within 48 hours before, or within 2 weeks after vaccination. The concurrent use of FluMist Trivalent with antiviral agents that are active against influenza A and/or B viruses has not been evaluated. If antiviral agents and FluMist Trivalent are administered concomitantly, revaccination should be considered when appropriate.