Adult: 120 mg once daily. Alternatively, 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: 2-11 years 30 mg bid; ≥12 years Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral Chronic idiopathic urticaria
Adult: 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Child: 6 months-<2 years 15 mg bid; 2-11 years 30 mg bid; ≥12 years 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
What are the brands available for Fexofenadine in Hong Kong?
Fexofenadine Should be taken on an empty stomach. Do not take w/ fruit juice.
Special Precautions
Patient with current or history of CV disease. Renal and hepatic impairment. Children. Pregnancy and lactation.
Adverse Reactions
Cardiac disorders: Palpitations, tachycardia. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, dyspepsia. General disorders and administration site conditions: Fatigue. Immune system disorders: Hypersensitivity reactions (e.g. angioedema, chest tightness, flushing). Nervous system disorders: Headache, drowsiness, dizziness. Psychiatric disorders: Insomnia, nervousness, sleep disorders or nightmares. Skin and subcutaneous tissue disorders: Rash, urticaria, pruritus.
Monitoring Parameters
Monitor relief of symptoms.
Overdosage
Symptoms: Dizziness, drowsiness, fatigue and dry mouth. Management: Symptomatic and supportive treatment.
Drug Interactions
Increased plasma concentrations with erythromycin and ketoconazole. Reduced bioavailability and absorption with antacids containing Al and Mg.
Food Interaction
Decreased bioavailability with high-fat meals, fruit juice (e.g. apple, grapefruit, orange).
Lab Interference
May suppress the wheal and flare reactions to skin test antigens.
Action
Description: Mechanism of Action: Fexofenadine is a non-sedating antihistamine and an active metabolite of terfenadine. It competes with histamine for H1-receptor on effector cells in the blood vessels, gastrointestinal tract and respiratory tract. Onset: 2 hours. Duration: 24 hours. Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract. Bioavailability: Approx 33%; decreased with high-fat meals, fruit juice. Time to peak plasma concentration: Approx 2.6 hours (conventional tab); 2 hours (orally disintegrating tab); approx 1 hour (susp). Distribution: Plasma protein binding: 60-70%, mainly to albumin and α1-acid glycoprotein. Metabolism: Undergoes minimal metabolism in the liver (approx 5%) into methylester metabolite. Excretion: Mainly via faeces (80%); urine (12%, as unchanged drug). Elimination half-life: 14.4 hours.
Chemical Structure
Fexofenadine Source: National Center for Biotechnology Information. PubChem Database. Fexofenadine, CID=3348, https://pubchem.ncbi.nlm.nih.gov/compound/Fexofenadine (accessed on Jan. 20, 2020)
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