Hypersensitivity. Patients w/ severe HTN, severe coronary artery disease; patients on MAOIs. Should not be used in newborn or premature infants & in treating lower resp tract symptoms including asthma. Post-op management in childn <18 yr following tonsillectomy &/or adenoidectomy. Childn <12 yr.
Elderly or debilitated patients. Severe impairment of renal or hepatic function. May impair ability to drive or operate machinery. May cause psychological dependence, physical dependence & tolerance. Should only be used to treat acute moderate pain in childn >12 yr, & only if it cannot be relieved by other painkillers eg, paracetamol or ibuprofen. Adolescents 12-18 yr who have other risk factors that may increase sensitivity to the resp depressant effects of codeine. Patients known to be ultra-rapid metabolisers. Lactation.
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