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The patient should be on an appropriate lipid-lowering diet and should continue on this diet during treatment with EZETROL.
The recommended dose of EZETROL is 10 mg once daily, used alone, with a statin, or with fenofibrate. EZETROL can be administered at any time of the day, with or without food.
Use in Patients with Coronary Heart Disease and ACS Event History: For incremental cardiovascular event reduction in patients with coronary heart disease and ACS event history, Ezetrol 10 mg may be administered with a statin with proven cardiovascular benefit.
Use in the Elderly: No dosage adjustment is required for elderly patients.
Use in Pediatric Patients: Children and adolescents ≥ 10 years: No dosage adjustment is required.
Children < 10 years: No clinical data are available, therefore, treatment with EZETROL is not recommended.
Use in Hepatic Impairment: No dosage adjustment is required in patients with mild hepatic insufficiency (Child Pugh score 5 to 6). Treatment with ezetimibe is not recommended in patients with moderate (Child Pugh score 7 to 9) or severe (Child Pugh score > 9) liver dysfunction. (See Precautions.)
Use in Renal Impairment: No dosage adjustment is required for renally impaired patients.
Co-administration with bile acid sequestrants: Dosing of EZETROL should occur either ≥ 2 hours before or ≥ 4 hours after administration of a bile acid sequestrant.
