Esomeprazole Actavis

Esomeprazole

Treatment of GORD, ulcers in the stomach or upper part of the intestine that are infected by H. pylori in adults & ped patients ≥12 yr. NSAID-induced stomach ulcers, Zollinger-Ellison syndrome, prolonged treatment after prevention of rebleeding ulcers w/ IV esomeprazole in adults.

Adult & childn ≥12 yr Treatment of heartburn caused by GORD Gullet has not been damaged 20 mg daily. Gullet slightly damaged 40 mg once daily for 4 wk. Treatment of ulcers caused by H. pylori infection 20 mg bd for 1 wk. Adult & childn ≥18 yr Treatment of NSAID-induced stomach ulcers 20 mg once a day for 4-8 wk. Prevention of NSAID-induced stomach ulcers 20 mg once a day. Zollinger-Ellison syndrome 40 mg bd. Prolonged treatment after prevention of rebleeding of ulcers w/ IV esomeprazole 40 mg once a day for 4 wk.

May be taken with or without food: Swallow whole, do not chew/crush. For patients w/ swallowing difficulties, disperse tab in ½ glass of non-carbonated water. Do not use other liqd. Stir until tab breaks up & drink immediately or w/in 30 min. Rinse the glass w/ ½ glass of water & drink. Alternatively, mix tab w/ water & give via a gastric tube.

Allergy to esomeprazole or to other proton-pump inhibitor (eg, pantoprazole, lanzoprazole, rabeprazole, omeprazole). Concomitant use w/ nelfinavir. Childn <12 yr.

Severe liver or kidney problems. Very infrequent cases of subacute cutaneous lupus erythematosus (SCLE). Discontinue if lesions occur, especially in sun-exposed areas of the skin & if accompanied by arthralgia. Patient losing a lot of wt for no reason & w/ problems swallowing, stomach pain or indigestion, vomits food or blood, blood-stained faeces; concomitant w/ clopidogrel; patients w/ osteoporosis or taking corticosteroids. Long-term (a year or longer) & multiple daily dose PPI therapy may increase the risk for osteoporosis-related fracture of the hip, wrist or spine. Patient should use the lowest dose & shortest duration of PPI therapy appropriate to the condition being treated.  Hypomagnesemia may occur in prolonged treatment or in concomitant w/ digoxin or drugs that may cause hypomagnesemia (eg, diuretics). Increased risk of GI infections eg, Salmonella, Campylobacter & possibly C. difficile. Patients w/ intolerance to some sugars. If affected by dizziness & blurred vision, do not drive or use machines. Pregnancy & lactation.

Headache, effects in stomach or gut (diarrhoea, stomach pain, constipation flatulence), nausea or vomiting.

Do not take w/ nelfinavir. Caution in concomitant w/ atazanavir, clopidogrel, ketoconazole, itraconazole or voriconazole, erlotinib, citalopram, imipramine or clomipramine, diazepam, phenytoin, blood-thinning medicines eg, warfarin, tacrolimus, rifampicin, St John's wort; cilostazol, cisapride, digoxin. May elevate & prolong serum levels of methotrexate &/or its metabolite, possibly leading to methotrexate toxicities.

Antacids, Antireflux Agents & Antiulcerants

A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

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