EPLERENONA PENTAFARMA TABLETS (eplerenone) is contraindicated in all patients with the following: hypersensitivity to EPLERENONA PENTAFARMA TABLETS; patients with clinically significant hyperkalemia; severe hepatic impairment (Child-Pugh Class C); serum potassium >5.0 mmol/L at initiation; severe renal impairment [eGFR <30 mL/min/1.73 m2]; concomitant use with potassium-sparing diuretics, potassium supplements or strong CYP3A4 inhibitors such as ketoconazole, itraconazole, nefazodone, telithromycin, clarithromycin, ritonavir, and nelfinavir (see Interactions and Dosage & Administration).
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