Sign Out
Pregnancy: Animal studies by the oral route have shown reproductive toxicity at high systemic exposure (see Pharmacology: Toxicology: Preclinical Safety Data under Actions).
Clinical experience with locally applied adapalene and benzoyl peroxide in pregnancy is limited but the few available data do not indicate harmful effects in patients exposed in early pregnancy.
Due to the limited available data and because a very weak cutaneous passage of adapalene is possible, EPIDUO should not be used during pregnancy.
In case of unexpected pregnancy, treatment should be discontinued.
Lactation: No study on animal or human milk transfer was conducted after cutaneous application of EPIDUO (adapalene/benzoyl peroxide) Gel.
EPIDUO should be used with caution in breast-feeding women and only on areas away from the chest.
To avoid contact exposure of the infant, application of EPIDUO to the chest should be avoided when used during breast-feeding.
Continue with Google